Lusternik-Schnirelmann invariants in proper homotopy theory

We introduce and study proper homotopy invariants of the Lusternik-Schnirelmann type, p-cat (-), p-Cat(-), and cat e(-) in the category of Γ2-locally compact spaces and proper maps. As an application, Rn (n Φ 3) is characterized as (i) the unique open manifold X with p-Cat(ΛΓ) = 2, or (ii) the unique open manifold with one strong end and p-cat( c) = 2

Fostering the Sustainable Development Goals from an Ecosystem Conducive to the SE: The Galician’s Case

The special alignment of the principles and effects of the social economy (SE) with the Sustainable Development Goals (SDGs) renders this area especially suitable for the implementation of the 2030 Agenda and the achievement of these goals, favoring a paradigm shift towards a new economic system that reconciles growth and sustainability. In this context, governments and institutions can moderate or accelerate this path, with the implementation of a series of policies to promote and drive the social economy. In Spain, responsibility for the design and implementation of such policies is transferred to sub-central governments, known as autonomous communities. Galicia is the first Spanish autonomous community to have its own Act on SE. This article explains the promotion strategy established in this region, which has resulted in an ecosystem favorable to the development and consolidation of the Galician SE, based on a combination of public policies with synergistic effects. The outcome of this ecosystem could have a significant impact on the achievement of several of the Sustainable Development Goals (SDGs), especially the promotion of equal opportunities (SDG 5), the promotion of decent work and economic growth (SDG 8), and the reduction of inequalities (SDG 10The research reported was partially supported by Grant TR811A-15-009-19 from the Xunta de Galicia to Maria BastidaS

Design considerations for a low-noise CMOS image sensor

This paper reports a Low-Noise CMOS Image Sensor. Low-noise operation is achieved owing to the combination of a noise-enhanced pixel, the use of a two-step ADC architecture and the analysis, and the optimization thereof, of the noise contributed by the readout channel. The paper basically gathers the sensor architecture, the ADC converter architecture, the outcome of the noise analysis and some basic characterization data. The general low-noise design framework is discussed in the companion presentation.Junta de Andalucía TIC 2012-2338Office of Naval Research (USA) N00014141035

Validación de movimientos de coordinación en extremidades superiores para rehabilitación virtual usando pendientes lineales

El desarrollo del presente trabajo se fundamenta en la importancia de apoyar los tratamientos de Rehabilitación Motriz por medio de Tecnología Informática para beneficio de los pacientes y especialistas del área. De acuerdo a un análisis realizado de las tecnologías existentes para la Rehabilitación Motriz, se ha identificado una serie de inconvenientes que limitan su uso en algunos tratamientos y por consecuencia los pacientes no continúan o no finalizan sus terapias, en este trabajo se propone emplear una herramienta de bajo costo (sensor Microsoft Kinect) que apoye en la captura de movimientos de los puntos clave de las extremidades superiores (manos, codos y hombros) usando pendientes lineales. Así mismo, se han realizado una serie de pruebas 21 usuarios, en donde se evaluaron sus movimientos mediante umbrales que determinaron si un ejercicio  fue realizado correctamente.</p

Some results on open edge guarding of polygons

This paper focuses on a variation of the Art Gallery problem that considers open edge guards. The “open” prefix means the endpoints of an edge where a guard is are not taken into account for visibility purposes. This paper studies the number of open edge guards that are sufficient and sometimes necessary to guard some classes of simple polygons.Fondo Europeo de Desarrollo RegionalEuropean Science FoundationMinisterio de Ciencia e InnovaciónFundação para a Ciência e a Tecnologi

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is a deficit in DC numbers and IFN-α production, which has been associated with disease severity. In this work, we described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers. Remarkably, previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients, while no restoration of integrin β7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed. These findings contribute to a better understanding of the immunological sequelae of COVID-19

Predictive Power of the "Trigger Tool" for the detection of adverse events in general surgery: a multicenter observational validation study

Background In spite of the global implementation of standardized surgical safety checklists and evidence-based practices, general surgery remains associated with a high residual risk of preventable perioperative complications and adverse events. This study was designed to validate the hypothesis that a new “Trigger Tool” represents a sensitive predictor of adverse events in general surgery. Methods An observational multicenter validation study was performed among 31 hospitals in Spain. The previously described “Trigger Tool” based on 40 specific triggers was applied to validate the predictive power of predicting adverse events in the perioperative care of surgical patients. A prediction model was used by means of a binary logistic regression analysis. Results The prevalence of adverse events among a total of 1,132 surgical cases included in this study was 31.53%. The “Trigger Tool” had a sensitivity and specificity of 86.27% and 79.55% respectively for predicting these adverse events. A total of 12 selected triggers of overall 40 triggers were identified for optimizing the predictive power of the “Trigger Tool”. Conclusions The “Trigger Tool” has a high predictive capacity for predicting adverse events in surgical procedures. We recommend a revision of the original 40 triggers to 12 selected triggers to optimize the predictive power of this tool, which will have to be validated in future studies

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group